Hippocampal volume assessment in temporal lobe epilepsy: How good is automated segmentation?

HR Pardoe; GS Pell; DF Abbott; GD Jackson

Journal article

Hippocampal volume assessment in temporal lobe epilepsy: How good is automated segmentation?

HR Pardoe, GS Pell, DF Abbott, GD Jackson

Epilepsia | Published : 2009

DOI: 10.1111/j.1528-1167.2009.02243.x

Abstract

PURPOSE: Quantitative measurement of hippocampal volume using structural magnetic resonance imaging (MRI) is a valuable tool for detection and lateralization of mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE). We compare two automated hippocampal volume methodologies and manual hippocampal volumetry to determine which technique is most sensitive for the detection of hippocampal atrophy in mTLE. METHODS: We acquired a three-dimensional (3D) volumetric sequence in 10 patients with left-lateralized mTLE and 10 age-matched controls. Hippocampal volumes were measured manually, and using the software packages Freesurfer and FSL-FIRST. The sensitivities of the techniques were compar..

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University of Melbourne Researchers

Heath Pardoe Author

David Abbott Author

Graeme Jackson Author

Related Projects (1)

Epilepsy: Molecular basis and mechanisms in the era of functional genomics

The team comprises of neurologists with a special interest in epilepsy (both adult and child) molecular geneticists, physiologists and brain..

Grants

Awarded by National Institute of Neurological Disorders and Stroke

Funding Acknowledgements

This study was supported by Program Grant 400121 from the National Health and Medical Research Council (NH&MRC), Australia. Heath Pardoe has salary part funded by Grant R37NS31146 (June 1, 2007-May 31, 2011) from NIH-NINDS, USA. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.Disclosure: None of the authors has any conflict of interest to disclose.